Descubre la gama de productos Listerine

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Listerine Zero

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La importancia de tener una boca sana

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Los aceites esenciales de Listerine

Listerine contiene 4 Aceites Esenciales:

-        Eucaliptol

-        Mentol

-        Salicilato de metilo

-        Timol

Los Aceites Esenciales son agentes antisépticos.

Los antisépticos son ampliamente usados en odontología como agentes activos en colutorios antiplaca y antigingivitis.

Los antisépticos son agentes químicos que eliminan microorganismos como bacterias y virus o interfieren en su reproducción o metabolismo.

Los Aceites Esenciales atacan a los microorganismos alterando sus paredes celulares y membranas e inhibiendo su actividad enzimática.

La eficacia de los antisépticos orales se atribuye normalmente a su actividad bactericida, pero algunos además actúan interfiriendo con la colonización bacteriana del diente y la superficie de la placa.

Los Aceites Esenciales frenan la agregación de las bacterias con especies colonizadoras Gram-positivas, retardan la multiplicación bacteriana, y extraen las endotoxinas de los patógenos Gram-negativos. Esto implica la reducción de la carga bacteriana, retardo en la maduración de la placa bacteriana, y disminución en la masa de la placa y patogenicidad.

Los colutorios de Aceites Esenciales son capaces de penetrar el biofilm de la placa.

 

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Effects of antimicrobial agents on oral biofilms in a saliva-conditioned flowcell

Oral bacteria form mixed-species biofilms known as dental plaque. Growth of these complex microbial communities is often controlled with the use of antimicrobial mouthrinses. Novel laboratory methods for testing the efficacy of antimicrobials in situ are necessary to complement current clinical testing protocols. In this study, we examined the effects of antimicrobial agents on a streptococcal biofilm grown in a saliva-conditioned flowcell. The flowcell coupled with confocal laser scanning microscopy enabled examination of growing oral biofilms in situ without disruption of the microbial community. Biofilms composed of Streptococcus gordonii DL1 were grown in an in vitro flowcell and treated with several commercially available antimicrobial mouthrinses containing essential oils, triclosan, cetylpyridinium chloride/domiphen or chlorhexidine. The results of this study revealed varying abilities of the antimicrobial agents to cause cellular damage on the growing biofilm in situ. This study therefore demonstrated the usefulness of the flowcell in the rapid assessment of antimicrobial efficacy.

♦ Foster JS et al. Biofilm Journal 2004; 1: 3-10

 

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Effects of sublethal exposure to an antiseptic mouthrinse on representative plaque bacteria

Although the mechanism responsible for the clinical antiplaque efficacy of oral antiseptics is generally considered to be primarily one of bactericidal activity, it has been suggested that oral antiseptics may have additional effects on bacteria exposed to sublethal levels. Studies reported herein, investigated the effects of sublethal levels of an essential oil-containing antiseptic mouthrinse (Listerine Antiseptic, Warner-Lambert Co., Morris Plains, NJ) on selected activities of representative plaque microorganisms using in vitro models. These studies demonstrated that sublethal exposure to the tested oral antiseptic can have significant effects in reducing intergeneric coaggregation, increasing bacterial generation time, and extracting endotoxin from Gram-negative bacteria. These in vitro activities can be correlated with features of plaque formation and pathogenicity seen in vivo; however, additional studies will be necessary to confirm that these mechanisms are, in fact, operative clinically.

♦ Fine DH et al. J Clin Periodont. 1996; 23: 444-451

 

Posted in Trabajos científicos | Comentarios desactivados

Antiseptic mouthrinse-induced microbial cell surface alterations

This study determined the effect of an essential oil-containing mouthrinse, Listerine Antiseptic, on microbial cell surface morphology using scanning electron microscopy. Twenty-four hour cultures of C. albicans, A. viscosus, S. sanguis, F. nucleatum, and A. actinomycetemcomitans were harvested and washed in buffer. Triplicate samples were overlaid on poly-L-lysine coated coverslips, immersed in either Listerine or buffer for 30 seconds, fixed in glutaraldehyde followed by post-fixing in 1% osmium tetroxide, dehydrated, and embedded in Peldri II. Exposure of the microorganisms to Listerine Antiseptic for 30 seconds resulted in distinct morphological alterations of cell surfaces suggestive of loss of cell surface integrity. The extent of alteration varied among the structurally different species; cell surface roughening was mild in S. sanguis but extensive in the other microorganisms which developed distinct surface blebs and other abnormalities after the 30-second exposure. These results suggest that a brief exposure to Listerine produces significant morphological changes which may be associated with cell death and may help explain the alteration of surface-associated activities demonstrated in previous studies.

♦ Kubert D et al. Am J Dent. 1993; 6: 277-279

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Effects of sublethal exposure to an antiseptic mouthrinse on representative plaque bacteria

Although the mechanism responsible for the clinical antiplaque efficacy of oral antiseptics is generally considered to be primarily one of bactericidal activity, it has been suggested that oral antiseptics may have additional effects on bacteria exposed to sublethal levels. Studies reported herein, investigated the effects of sublethal levels of an essential oil-containing antiseptic mouthrinse (Listerine Antiseptic, Warner-Lambert Co., Morris Plains, NJ) on selected activities of representative plaque microorganisms using in vitro models. These studies demonstrated that sublethal exposure to the tested oral antiseptic can have significant effects in reducing intergeneric coaggregation, increasing bacterial generation time, and extracting endotoxin from Gram-negative bacteria. These in vitro activities can be correlated with features of plaque formation and pathogenicity seen in vivo; however, additional studies will be necessary to confirm that these mechanisms are, in fact, operative clinically.

♦ Fine DH et al.. J Clin Periodont. 1996; 23: 444-451

 

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The remineralization potential of an anticaries/antigingivitis mouthrinse

PURPOSE:

To assess the ability of a new formulation (Listerine with 0.022% NaF) to remineralize initially decalcified bovine enamel compared to a positive control, clinically established 0.022% NaF rinse.

METHODS:

A cyclic demineralization/remineralization in vitro model was utilized and the level of remineralization was monitored by examining the Knoop microhardness over 6 and 18 D/T/R cycles

RESULTS:

(1) both the test formulation and positive control rinses were statistically significantly effective in remineralizing artificial lesions in vitro; and (2) the test formulation performed “at least as good as” the positive control. These results support the concept that the remineralization potential of the fluoride rinse is not adversely affected by the addition of essential oils.

♦ Yu D et al. J Dent Res 2002: 81, abstr 0145.

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The caries prevention potential of an anticaries/antigingivitis mouthrinse. Effect of fluoride/essential oils-containing mouthrinse on the microhardness of demineralized bovine enamel

PURPOSE:

To assess the ability of a fluoride mouthrinse containing a fixed combination of essential oils (thymol, menthol, eucalyptol, and methyl salicylate) to inhibit demineralization as compared with that of a clinically established NaF rinse.

METHODS:

Inhibition in sound bovine enamel to demineralization was assessed utilizing a cyclic T/R/D (treatment/remineralization/demineralization) in vitro model where Knoop microhardness was monitored over 6, 12, and 18 T/R/D cycles.

RESULTS:

Both fluoride-containing mouthrinses resulted in statistically significant increase in microhardness when compared to the non-fluoride control mouthrinse, possibly demonstrating and validating the in vitro model’s ability to parallel the clinically established benefit of a 0.022% NaF rinse to inhibit demineralization. In addition, the test formulation was shown to be “at least as good as” the NaF positive control in increasing enamel microhardness following each of the 6, 12, and 18 T/R/D cycles.

♦ Yu D et al. Am J Dent. 2004 Jun;17(3):216-8.

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